Qingwen Xie,1 Tian Zhou,2 Lawrence Yen,2 Mina Shariff,3 Tuong Nguyen,3 Kenneth Kami,3 Pingping Gu,3 Liang Liang,2 Jianyu Rao,2 Rong Shi11Department of Preventive Medicine, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China; 2Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, 3Department of Research, DRM Resources, Costa Mesa, CA, USABackground: Osteoarthritis is a common chronic disease affecting aged populations. Conventional therapies tend to result in side effects when used long-term. Arthro-7 (Robinson Pharma, Orange County, CA, USA) has been used by osteoarthritis patients for more than 10 years in the USA and has showed promising effects at relieving osteoarthritis-related symptoms. A previous small, double-blind study has shown some positive effects of Arthro-7 in relieving symptoms of osteoarthritis. The current study was performed specifically in osteoarthritis patients with mild to moderate arthralgia.Methods: A total of 100 subjects over the age of 50 years old who were diagnosed with osteoarthritis and had at least one of the related symptoms were recruited to the study. After primary evaluation, 64 eligible males and females with mild or moderate degrees of arthralgia were randomly assigned 12-week treatment with either Arthro-7 or placebo. The primary outcome measurement was changes in the scores of the related symptoms before and after treatment, using the modified Western Ontario and McMaster Universities Arthritis Index (WOMAC) 3.1 questionnaire. Prior to and at the end of the study, evaluations of symptom scores were recorded. Additionally, self-reported overall changes were recorded at the end of 2, 4, and 8 weeks of treatment and at the end of the study (12 weeks).Results: Arthro-7 improved most symptoms significantly compared with placebo, as indicated by significant reductions in symptom scores. In the Arthro-7 group, 74.5% of the participants reported symptom improvement over the study period versus only 16.3% in the placebo group.Conclusion: In this study, Arthro-7 has shown potent effects in improving and relieving osteoarthritis-related symptoms, particularly joint pain, anchylosis, and difficulty going down stairs.Keywords: joint pain, anchylosis, arthroncus, WOMAC 3.1Corrigendum for this paper has been published
They are also famous as green caviar. Not only in Japan, it is also famous in Philippines and Malaysia where it is referred as lato or latok.Do you know why our coastal neighbors live longer than any other natives in the world May be it is because of the rich nutrients of sea grapes.
When refering to evidence in academic writing, you should always try to reference the primary (original) source. That is usually the journal article where the information was first stated. In most cases Physiopedia articles are a secondary source and so should not be used as references. Physiopedia articles are best used to find the original sources of information (see the references list at the bottom of the article).
We compared the treatment effectiveness between guselkumab and adalimumab in patients with pustulotic arthro-osteitis (PAO). In addition, we performed peripheral blood immunophenotyping to elucidate the immunological background and analyzed the impact of therapeutic drugs to verify the validity of immunological phenotypes as therapeutic targets.
The IL-23/Th17 cell axis is the primary driver of skin inflammation in psoriasis. It was reported that gene expression in psoriatic skin lesions was enhanced through IL-17 and its pathways and that treatment with guselkumab decreased the expression of IL-17-related factors and resulted in the resolution of skin lesions . The present study compared the peripheral immune cell phenotypes of patients with PAO with those of HCs and patients with PsA. The results showed that the proportion of activated Th1 cells was significantly lower in patients with PAO than in HCs and patients with PsA, whereas the proportion of activated Th17 cells was significantly higher in patients with PAO (Table 4). We considered the possibility that previous (concomitant) DMARDs may have reduced activated Th1 cells or Th17 cells; however, as shown in Supplementary Table S2, no significant difference was observed between cases with concomitant DMARD use (N=16) and those without concomitant use (N=6). In other words, it was suggested that the history of DMARD use may not affect activated Th1/Th17 cells. On the other hand, the cytokine assay system used in this study detects both free cytokines and drug combined form; we could not measure the free TNF-α levels in the adalimumab. This might be one of the significant reasons that consistent changes in serum TNF-α levels were not observed in the adalimumab group. In addition, although serum samples were not thawed until cytokine measurement, cytokine levels might be influenced by the freeze/thaw cycle of the serum samples.
An arthrogram is an X-ray exam of a joint, using a contrast agent and fluoroscopy (a live motion X-Ray). The arthrogram may include additional CT (for cross-sectional views) or MRI (for magnetic resonance) imaging. Though the contrast material may vary, in all cases an arthrogram outlines the structures in the joint and reveals information to the radiologist.
An arthrogram is used to reveal the function of cartilage in a joint. Often this procedure is used to image the knee and hip joints, and it is also used when investigating activity in the shoulders, elbows, ankles and wrists. If you have unexplained joint discomfort or pain, or if you have a known issue, such as a tear in the rotator cuff, your doctor may order an arthrogram to diagnose or monitor the problem.
The doctor uses fluoroscopy, a kind of live motion X-ray, to monitor the injection and activity of the contrast. If you are having a CT or MRI arthrogram, you will then proceed to that scanner to continue painless imaging of the joint. Afterward, the affected joint should be rested for 12 hours.
An arthrogram is beneficial in that it allows clinicians to get much more clarity on joint health than is provided by a standard X-Ray, which does not show cartilage accurately. MRI, with contrast, accurately shows tears or lesions in cartilage, as well as problems with ligaments, tendons or other joint capsules. It is minimally invasive and presents little risk to the patient. 59ce067264